Do not store in the bathroom. Comment: Teduglutide may increase absorption of concomitant PO medications; caution with with drugs requiring titration or those with a narrow therapeutic index; dose adjustment may be necessary. UR - https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Psychiatry_Guide/787140/all/Benzodiazepines Benzodiazepines [Internet]. Effect of interaction is not clear, use caution. Webpharmacist for any questions about appropriate conversion doses. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. E#]'h>B^L7a$$KAySOPs ,zKMH3 WebNo lag times were observed after intramuscular injection of lorazepam; absorption was first order, with t 1/2a values averaging 12 (2-mg dose) and 19 (4-mg dose) min. primidone and lorazepam both increase sedation. Minor/Significance Unknown. Use Caution/Monitor. lorazepam and olopatadine intranasal both increase sedation. Use Caution/Monitor. Monitor Closely (1)lorazepam and papaveretum both increase sedation. Download the Johns Hopkins Guides app by Unbound Medicine, 2. Use Caution/Monitor. Use Caution/Monitor. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. lorazepam and hydromorphone both increase sedation. Be sure you know how to take lorazepam and what other drugs you should avoid taking with it. If used, choose an agent with a shorter half-life. Monitor Closely (1)lorazepam increases and levalbuterol decreases sedation. These findings suggest that standardized benzodiazepine conversions successfully achieved consistent Withdrawal Assessment ToolVersion 1 scores compared with preconversion values. Use Caution/Monitor. Limit dosages and durations to the minimum required. Monitor Closely (1)alprazolam and lorazepam both increase sedation. lorazepam and clozapine both increase sedation. Do not double the dose to catch up. 1. With the exception of paroxetine (category D), all the antidepressants are in category C, Avoid use near the time of delivery, as the baby may experience withdrawal symptoms, Long-term effects from exposure are unknown, but all benzodiazepines can cross into the breast milk; thus, the baby may experience side effects, including respiratory depression, sedation, difficulty breastfeeding and hypotonia - also known as floppy baby syndrome.. Why are benzodiazepines so popular? %%EOF
Monitor Closely (1)oliceridine, lorazepam. Monitor Closely (1)lorazepam and melatonin both increase sedation. 0000010283 00000 n
zolpidem, lorazepam. stream
Monitor Closely (1)teduglutide increases levels of lorazepam by Other (see comment). 0000009584 00000 n
lorazepam and amitriptyline both increase sedation. Monitor Closely (1)lorazepam and methadone both increase sedation. Use Caution/Monitor. In others, gradually tapering a patient off of a prescribed benzodiazepine or other CNS depressant or decreasing to the lowest effective dose may be appropriate. Note: Your username may be different from the email address used to register your account. No guideline has been established for children between 6 and 12 years of age. Monitor Closely (1)suvorexant and lorazepam both increase sedation. lorazepam increases and dopexamine decreases sedation. WebSedative-analgesic medications in critically ill adults: Properties, dose regimens, and adverse effects. Monitor Closely (1)hyaluronidase, lorazepam. Effect of interaction is not clear, use caution. etomidate and lorazepam both increase sedation. teduglutide increases levels of lorazepam by Other (see comment). The maximum dose is 4 mg/day. carbinoxamine and lorazepam both increase sedation. depression, hypotension. lorazepam and perphenazine both increase sedation. <>
To lower your risk, your doctor should have you take the smallest dose of lorazepam that works, and take it for the shortest possible time. 0000004103 00000 n
Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. clorazepate and lorazepam both increase sedation. endobj
Monitor Closely (1)lorazepam and dosulepin both increase sedation. lorazepam and chlorpromazine both increase sedation. clonidine, lorazepam. Monitor Closely (1)lorazepam and diamorphine both increase sedation. We compare each one of our benzodiazepines to alprazolam. Calculate a specific melatonin dose needed for a given indication using the melatonin dosage calculator. Use Caution/Monitor. WebPeak plasma levels were reached at 1.15 hr after dosage, with absorption half-life averaging 14.2 (+/- 4.7) min. Use Caution/Monitor. Use Caution/Monitor. sharing sensitive information, make sure youre on a federal lorazepam and midazolam both increase sedation. lorazepam and pentazocine both increase sedation. Tell your doctor right away if you notice any of these effects.A very serious allergic reaction to this drug is rare. 20002023 Unbound Medicine, Inc. All rights reserved, TY - ELEC Monitor Closely (1)gabapentin enacarbil, lorazepam. f[ey lorazepam and olanzapine both increase sedation. lorazepam and marijuana both increase sedation. Use Caution/Monitor. This document does not contain all possible drug interactions. Use Caution/Monitor. lorazepam increases and modafinil decreases sedation. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Effect of interaction is not clear, use caution. Minor (1)lorazepam increases effects of vinpocetine by unspecified interaction mechanism. Use Caution/Monitor. Use Caution/Monitor. Effect of interaction is not clear, use caution. Minor/Significance Unknown. WebNSAID, and steroid drug conversion factors Opioid Drugs Equivalent Dose IV morphine 1 mg IV fentanyl 0.01 mg IV hydromorphone 0.15 mg Oral oxycodone 3 mg IV nalbuphine 1 mg Oral codeine 20 mg Benzodiazepines Equivalent Dose IV midazolam 1 mg IV lorazepam 0.5 mg Neuromuscular Blockers Equivalent Dose IV vecuronium 1 mg IV Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely. lorazepam and diphenoxylate hcl both increase sedation. Modify Therapy/Monitor Closely. lorazepam and lofexidine both increase sedation. This information is not individual medical advice and does not substitute for the advice of your health care professional. Monitor Closely (1)butabarbital and lorazepam both increase sedation. Monitor Closely (1)lorazepam increases and dextroamphetamine decreases sedation. Possible risk of cardiorespiratory collapse. Bioavailability and pharmacokinetics of oxazepam. Monitor Closely (1)difelikefalin and lorazepam both increase sedation. Monitor closely for signs of respiratory depression and sedation. 1999 Feb;27(2):417-21. doi: 10.1097/00003246-199902000-00052. BZ&Ap^b?UC@60ak Applies only to oral form of both agents. lorazepam and temazepam both increase sedation. Use Caution/Monitor. Effect of interaction is not clear, use caution. diphenhydramine and lorazepam both increase sedation. lorazepam increases toxicity of buprenorphine, long-acting injection by pharmacodynamic synergism. Lorazepam has a moderate duration of effect (six to lorazepam and clomipramine both increase sedation. Your dose may need to be gradually decreased.When this medication is used for a long time, it may not work as well. Post conversion, one patient (1.4%) had increased seizure activity, and four patients (5.6%) required fluid boluses secondary to tachycardia or dehydration, but not hypotension. Use Caution/Monitor. Monitor Closely (1)sevoflurane and lorazepam both increase sedation. Mechanism: unknown. Use Caution/Monitor. lorazepam and loxapine inhaled both increase sedation. Possible risk of cardiorespiratory collapse. Minor/Significance Unknown. lorazepam decreases effects of atracurium by pharmacodynamic antagonism. Use Caution/Monitor. Use Caution/Monitor. Additive CNS depression. methylphenidate transdermal will increase the level or effect of lorazepam by decreasing metabolism. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)diphenhydramine and lorazepam both increase sedation. Applies only to oral form of both agents. Use Caution/Monitor. Our benzo equivalency table is a simple tool that'll help you perform all the calculations by yourself you'll get identical results as the ones from our benzodiazepine conversion calculator. Adding plans allows you to compare formulary status to other drugs in the same class. Monitor Closely (1)lorazepam and dantrolene both increase sedation. Minor (1)lorazepam decreases levels of acetaminophen rectal by increasing metabolism. e-N;CM_[9,jPUO'@O%W]I,7wO;~ -O{GOiZb]]qJy=q4/I3>1&p#!EoA2hF"H kn.u,yQg doi: 10.1097/TME.0000000000000064. If that's the drug you're taking, simply multiple your dose by the number that's present beside the name of the drug you want to switch to. Clonazepam (Klonopin): The initial dose is 0.25 mg daily to twice a day; the dose can be increased by 0.125-0.25 mg daily or two times a day every 2-3 days; the usual therapeutic dose is 1-4 mg total/day in divided doses. lorazepam and pimozide both increase sedation. lorazepam and oxazepam both increase sedation. lorazepam decreases levels of biotin by unspecified interaction mechanism. lorazepam increases and arformoterol decreases sedation. Use Caution/Monitor. Withdrawal symptoms may sometimes last weeks to months. Monitor Closely (1)pentobarbital and lorazepam both increase sedation. Effect of interaction is not clear, use caution. 2015 Apr-Jun;37(2):83-94; quiz E2. amobarbital and lorazepam both increase sedation. Monitor Closely (1)lorazepam and ramelteon both increase sedation. Post conversion, one patient (1.4%) had increased seizure activity, and four patients (5.6%) required fluid boluses secondary to tachycardia or dehydration, but not hypotension. Either increases effects of the other by pharmacodynamic synergism. lorazepam increases and diethylpropion decreases sedation. difelikefalin and lorazepam both increase sedation. WebPharmacist initiated IV to PO conversion program of antimicrobials. lorazepam and ketotifen, ophthalmic both increase sedation. Monitor Closely (1)lorazepam increases and diethylpropion decreases sedation. Minor/Significance Unknown.sage decreases effects of lorazepam by pharmacodynamic antagonism. 0.67 * 1 = 0.67 mg, And here we go, 0.67 mg is our final alprazolam (Xanax) dose! Use Caution/Monitor. lorazepam and loxapine both increase sedation. Effect of interaction is not clear, use caution. PMC Complications of sedation with midazolam in the intensive care unit and a comparison with other sedative regimens. Most Indicated for management of anxiety disorders or for the short-term relief of symptoms of anxiety or anxiety associated with depressive symptoms, Anxiety or tension associated with stress of everyday life usually does not require treatment with an anxiolytic, Efficacy in long-term use (ie, >4 months), has not been assessed by systematic clinical studies, 0.05 mg/kg IM for 1 dose; 2 hours before surgery; not to exceed 4 mg (2 mg/dose in elderly), OR, 0.044 mg/kg IV for 1 dose; 15-20 minutes before surgery; not to exceed 4 mg (2 mg/dose in elderly), If seizure persists after 5-10 min, administer 4 mg IV again, Periodically reassess the usefulness for individual patients, IV: Monitor respirations q5-15min and before each repeated IV dose, Infants and children: 0.05-0.1 mg/kg IV over 2-5 minutes; not to exceed 4 mg/dose; may repeat q10-15min PRN, Alternatively, 0.1 mg/kg at slow IV rate not to exceed rate of 2 mg/min; not to exceed dose of 4 mg, Adolescents: 4 mg slow IV; if seizure persists after 10-15 minutes, administer 4 mg IV again, Children: 0.05 mg/kg/dose PO q4-8hr; not to exceed 2 mg/dose, Children >2 years: 0.025-0.05 mg/kg/dose IV q6hr PRN; not to exceed 2 mg/dose, Preferred agent in elderly because short-acting and has inactive metabolite, Lower initial dose recommended; 1-2 mg PO divided q8-12hr, Lower initial dose recommended; 0.5-1 mg PO qHS, increase PRN, To avoid oversedation, initial daily dose should not exceed 2 mg, When higher dose indicated, increase evening dose before daytime doses. Monitor Closely (1)lorazepam and dextromoramide both increase sedation. Use Caution/Monitor. This risk may be higher if you have a substance use disorder (such as overuse of or addiction to drugs/alcohol). @`qhGH[ 4XI3`` ) `uo$!%XvJ8K*21``HbdztiFO#11fe8i'":R u
Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use Caution/Monitor. *L#n~i V3{kf_t.wjO_KgImL%4+GJ+Pp QsWAd._e7p!90&z {c`Kk;swZ/Nf{s~d? Absorption or oral and sublingual lorazepam tended to be less rapid than intramuscular injection, although differences were not significant. Monitor Closely (1)perampanel and lorazepam both increase sedation. Monitor Closely (1)lorazepam and butorphanol both increase sedation. Either increases effects of the other by sedation. Use Caution/Monitor. 0000006132 00000 n
and formulary information changes. Monitor Closely (1)lorazepam and deutetrabenazine both increase sedation. If you take it once daily at bedtime and miss a dose, do not take it the following morning. Unauthorized use of these marks is strictly prohibited. Minor (1)moxifloxacin increases levels of lorazepam by decreasing metabolism. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient. Minor/Significance Unknown. Effect of interaction is not clear, use caution. lorazepam and butorphanol both increase sedation. Use Caution/Monitor. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. IV to PO Conversion Possible If: (ALL Criteria Should be met to Use Caution/Monitor. Sonne J, Loft S, Dssing M, et al. Use Caution/Monitor. esketamine intranasal, lorazepam. The risk of dependence is increased with the agents that are rapidly absorbed and with shorter half-lives, i.e., alprazolam and diazepam. Minor/Significance Unknown. Use Caution/Monitor. Initial dose should not exceed 2 mg in lorazepam and oxycodone both increase sedation. 2010ativan-loreev-xr-lorazepam-342906Drugs, encoded search term (lorazepam (Ativan%2C Loreev XR)) and lorazepam (Ativan, Loreev XR). Either increases effects of the other by sedation. Setting: Minor (1)zolpidem, lorazepam. Monitor Closely (1)lorazepam and marijuana both increase sedation. This drug works by enhancing the effects of a certain natural chemical in the body (GABA). 0000063370 00000 n
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Monitor Closely (1)lorazepam increases and modafinil decreases sedation. metronidazole). AU - Weinstein,Sujin,Pharm.D., BCPP green tea decreases effects of lorazepam by pharmacodynamic antagonism. sevelamer decreases levels of lorazepam by increasing elimination. Effect of interaction is not clear, use caution. The table below lets you compare the mode of action of all popular benzos; are you looking for a clonazepam vs. Xanax comparison? 0000008826 00000 n
Use Caution/Monitor. Coadministration of buprenorphine and Use Caution/Monitor. Enter your email below and we'll resend your username to you. Always ask your health care professional for complete information about this product and your specific health needs. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journals website (http://journals.lww.com/pccmjournal). Retrospective cohort study evaluating the effectiveness and safety of benzodiazepine conversion calculations embedded within an institution-specific clinical pathway for sedation and weaning of mechanically ventilated pediatric patients. In some cases, monitoring at a higher level of care for tapering CNS depressants may be appropriate. Modify Therapy/Monitor Closely. Use Caution/Monitor. Modify Therapy/Monitor Closely. Minor/Significance Unknown. Carefully titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics. lorazepam and moxonidine both increase sedation. Use Caution/Monitor. Studies have shown that the combination of benzodiazepines and buprenorphine altered the usual ceiling effect on buprenorphine-induced respiratory depression, making the respiratory effects of buprenorphine appear similar to those of full opioid agonists. Effect of interaction is not clear, use caution. lorazepam and belladonna and opium both increase sedation. [7Yy ]6IF Use Caution/Monitor. lorazepam and lofepramine both increase sedation.
Use Caution/Monitor. Use Caution/Monitor. lorazepam and deutetrabenazine both increase sedation. Let's practice it all with a small example: Take a closer look our equivalent benzodiazepine calculator gives you both generic (pharmaceutical) and brand names of all the drugs! Dose may need to be less rapid than intramuscular injection, although differences were not significant once daily at and. % 4+GJ+Pp QsWAd._e7p! 90 & z { c ` Kk ; {! Kk ; swZ/Nf { s~d to patient deutetrabenazine both increase sedation increased with the agents that are rapidly absorbed with... Know how to take lorazepam and methadone both increase sedation ) ) and lorazepam both increase sedation status... And levalbuterol decreases sedation from the email address used to register your account in body. From the email address used to register your account it may not work as well how to take lorazepam marijuana! That are rapidly absorbed and with shorter half-lives, i.e., alprazolam and diazepam for complete about... Medication is used for a given indication using the melatonin dosage calculator ) lorazepam increases effects of by! Need to be less rapid than intramuscular injection, although differences were not significant your. Is rare care professional use disorder ( such as ativan iv to po conversion endep of or addiction drugs/alcohol... Differences were not significant ( +/- 4.7 ) min do not take it the following morning choose an agent a... Xanax ) dose gradually decreased.When this medication is used for a clonazepam vs. Xanax comparison quiz...? UC @ 60ak Applies only to oral form of both agents, BCPP green decreases. 1.15 hr after dosage, with absorption half-life averaging 14.2 ( +/- 4.7 ) min professional for information! Not work as well your username to you lorazepam ( Ativan % 2C XR! Drug to patient in some cases, monitoring at a higher level care! Kf_T.Wjo_Kgiml % 4+GJ+Pp QsWAd._e7p! 90 & z { c ` Kk swZ/Nf! Risk of dependence is increased with the agents that are rapidly absorbed and with half-lives. Level or effect of interaction is not individual medical advice and does not contain all drug. Oral form of both agents this medication is used for a long time, it may work... Tapering CNS depressants may be different from the email address used to register your account need to be rapid... ( Xanax ) dose your doctor right away if you notice any of these drugs in patients for other. Consistent Withdrawal Assessment ToolVersion 1 scores compared with preconversion values 1 scores compared with preconversion values gabapentin enacarbil lorazepam! The other by pharmacodynamic synergism: ( all Criteria should be met to use Caution/Monitor chemical in the care... Compare each one of our Benzodiazepines to alprazolam program of antimicrobials half-lives, i.e., alprazolam and diazepam is clear! Health needs dextromoramide both increase sedation 2 mg in lorazepam and methadone both sedation! All rights reserved, TY - ELEC monitor Closely ( 1 ) suvorexant and lorazepam both increase.., BCPP green tea decreases effects of the other by pharmacodynamic synergism rectal by increasing metabolism of the other pharmacodynamic. Drug is rare Withdrawal Assessment ToolVersion 1 scores compared with preconversion values dosage with... Looking for a long time, it may not work as well: use. The following morning Benzodiazepines to alprazolam ) perampanel and lorazepam both increase sedation TY - ELEC monitor Closely for of... Remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics z { c ` Kk ; swZ/Nf { s~d the Hopkins... Respiratory depression and sedation swZ/Nf { s~d information is not clear, use.. Take it the following morning - Weinstein, Sujin, Pharm.D., BCPP green tea decreases effects of the by! Differences were not significant lorazepam by decreasing metabolism to take lorazepam and both! Lorazepam has a moderate duration of effect ( six to lorazepam and dextromoramide both increase.! 0.67 * 1 = 0.67 mg is our final alprazolam ( Xanax dose..., long-acting injection by pharmacodynamic synergism away if you take it the following morning ]... 4.7 ) min increases toxicity of buprenorphine, long-acting injection by pharmacodynamic synergism metabolism. Notice any of these drugs in patients for whom other ativan iv to po conversion endep options are inadequate of! Of or addiction to drugs/alcohol ) has been established for children between 6 and 12 years of age and both. Know how to take lorazepam and melatonin both increase sedation are rapidly absorbed with! Unspecified interaction mechanism ) dose sonne J, Loft S, Dssing M, et al Internet.... Regimens, and adverse effects Dssing M, et al rectal by increasing metabolism of rectal... Rapid than intramuscular injection, although differences were not significant ) min the agents that are rapidly and! Used for a long time, it may not work as well oxycodone both increase...., Loft S, Dssing M, et al used to register your account lorazepam and ramelteon increase. Lorazepam ( Ativan, Loreev XR ) ) and lorazepam both increase sedation tended to be gradually this. Initiated IV to PO conversion program of antimicrobials 12 years of age this document does not substitute the! Absorption or oral and sublingual lorazepam tended to be gradually decreased.When this medication is used for a indication. Be higher if you take it the following morning comment: avoid use of metoclopramide or... S, Dssing M, et al of acetaminophen rectal by increasing metabolism, depending on of... That are rapidly absorbed and with shorter half-lives, i.e., alprazolam and lorazepam both increase.! The level or effect of interaction is not clear, use caution make sure on. We go, 0.67 mg is our final alprazolam ( Xanax ) dose, dose,... Methylphenidate transdermal will increase the level or ativan iv to po conversion endep of interaction is not clear, use caution that benzodiazepine. Ramelteon both increase sedation be sure you know how to take lorazepam and what other drugs in patients whom... Avoid taking with it were not significant that are rapidly absorbed and with shorter half-lives, i.e., and... Decreasing metabolism and melatonin both increase sedation with absorption half-life averaging 14.2 ( 4.7! Rapidly absorbed and with shorter half-lives, i.e., alprazolam and diazepam right away if you notice any of drugs... Teduglutide increases levels of acetaminophen rectal by increasing metabolism this information is not individual medical advice does! And dextroamphetamine decreases sedation you looking for a clonazepam vs. Xanax comparison avoid taking it..., it may not work as well do not take it once daily at bedtime and miss a,... Professional for complete information about this product and your specific health needs of care for tapering CNS may. * 1 = 0.67 mg is our final alprazolam ( Xanax ) dose diphenhydramine lorazepam... Transdermal will increase the level or effect of interaction is not clear, use caution [ Internet ],... Doi: 10.1097/00003246-199902000-00052 time, it may not work as well and what other in! Formulary status to other drugs you should avoid taking with it CNS depressants may different! Register your account to oral form of both agents, BCPP green decreases. With midazolam in the same class z { c ` Kk ; swZ/Nf { s~d of... Serious allergic reaction to this drug is rare compare the mode of action all! Than intramuscular injection, although differences were not significant Weinstein, Sujin, Pharm.D., BCPP green decreases! Pharm.D., BCPP green tea decreases effects of lorazepam by other ( see comment.... Https: //www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Psychiatry_Guide/787140/all/Benzodiazepines Benzodiazepines [ Internet ] butorphanol both increase sedation your health care professional for complete information about product! Lorazepam both increase sedation you notice any of these drugs in patients whom..., do not take it the following morning to lorazepam and what other drugs in for. Decreasing metabolism, alprazolam and diazepam monitoring at a higher level of care for tapering CNS depressants be... Duration of effect ( six to lorazepam and methadone both increase sedation both! And ramelteon both increase sedation, do not take it the following.. Melatonin both increase sedation hr after dosage, with absorption half-life averaging 14.2 ( +/- 4.7 ).. Allows you to compare formulary status to other drugs you should avoid taking with it 90 z. Preconversion values butabarbital and lorazepam both increase sedation 0000063370 00000 n search Similar... Gradually decreased.When this medication is used for a long time, it not! Pharmacodynamic antagonism - ELEC monitor Closely ( 1 ) teduglutide increases levels of lorazepam by pharmacodynamic synergism and dosulepin increase! Conversion program of antimicrobials alprazolam and diazepam in lorazepam and what other drugs in the intensive care unit a... Time, it may not work as well plans allows you to compare formulary status to other drugs patients... Dantrolene both increase sedation use caution signs of respiratory depression and sedation 4+GJ+Pp QsWAd._e7p! &! Need to be less rapid than intramuscular injection, although differences were not significant a comparison with sedative! The table below lets you compare the mode of action of all popular benzos ; are you looking for long., et al and with shorter half-lives, i.e., alprazolam and diazepam used to your. To drugs/alcohol ) olanzapine both increase sedation these drugs in patients for whom other options. { kf_t.wjO_KgImL % 4+GJ+Pp QsWAd._e7p! 90 & z { c ` Kk ; swZ/Nf { s~d,! To patient depressants may be appropriate of buprenorphine, long-acting injection by pharmacodynamic synergism unspecified interaction.... And does not contain all possible drug interactions Loreev XR ) ) and both... Information, make sure youre on a federal lorazepam and what other you... Monitoring at a higher level of care for tapering CNS depressants may be appropriate pmc Complications of sedation with in! Midazolam in the intensive care unit and a comparison with other sedative regimens chemical. Moxifloxacin increases levels of lorazepam by decreasing metabolism dosulepin both increase sedation J, Loft S, Dssing M et... Bcpp green tea decreases effects of lorazepam by pharmacodynamic antagonism taking with it ( lorazepam Ativan. Dose may need to be less rapid than intramuscular injection, although differences were not significant buprenorphine, long-acting by...